The PROUD study is an initiative of the University Medical Center Utrecht (divisions: Julius Center and Medical Microbiology) and Saltro. The study focuses on the introduction of molecular diagnostic techniques for primary care acute diarrhea patients.
Our primary objective is to investigate the effects of the introduction of PCR diagnostics for acute diarrhea primary care patients on pathogen detection rates, health outcomes and costs. Successive objectives are 1) the effects of PCR introduction on general practitioner’s guideline adherence, 2) the proven etiology of acute IID in primary care patients using highly sensitive, multiplex PCR techniques and feasibility of using routine care data as passive laboratory surveillance system for viral enteropathogens, 3) the etiologic role of IID in the development of IBS in acute diarrhea primary care patients, 4) the clinical utility and cost effectiveness of detection of toxin producing E. Coli spp. in primary care patients with acute diarrhea using molecular PCR techniques.